The Saxonian Anorexia Nervosa Study (SANS) cohort comprises predominantly adolescent and young adult female participants recruited through the Dresden-based Eating Disorder Research and Treatment Center and the Translational Developmental Neuroscience Section at TU Dresden/University Hospital Carl Gustav Carus. A key feature of the cohort is its multimodal and partly longitudinal design: patients with acute AN are assessed shortly after admission in an acutely underweight state, with subsets reassessed after short-term weight restoration; comparison groups include healthy controls and, in some studies, individuals who are long-term weight-recovered from AN. Assessments combine MRI-based measures with detailed clinical phenotyping and, depending on the study, peripheral biological measures such as leptin, inflammatory markers, or neurofilament light. This design has been used to investigate which neurobiological alterations are associated with the acute undernourished state, which normalize during weight restoration, and which may persist beyond acute illness.