Advancing Personalized Medicine in Anorexia Nervosa: a Companion Biomarker-driven Approach
The BIOREXIA project is an international collaboration, which aims to fundamentally change Anorexia nervosa (AN) care by identifying and validating biomarkers that can guide personalized treatments. Biomakers such as leptin and ghrelin signaling are crucial for the regulation of appetite and metabolism. The study not only analyzes existing blood samples focusing on those biomakers but also integrates results from advanced brain imaging techniques (MRI) to examine cortical thickness, which can be a potential predictor of disease severity and relapse risk. Patients can therefore be classified based on their individual biological and neurological profiles. This helps clinicians to determine the intensity and type of treatment needed and consequently improves patient outcomes, reduces the risk of relapse and contributes to a more sustainable healthcare system.