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Daniel Geisler

Research Statement

I am interested in aberrations of cognitive flexibility and motivation in eating disorders, in particular anorexia nervosa. In order to understand the underlying biological mechanisms I examine functional, resting state and structural MRI data using well-established software suites, such as SPM, Freesurfer, and FSL. With the goal to preserve interoperability of these heterogeneous tools I introduced Nipype, which allows an efficient and state-of-the-art processing of our acquired MRI data.

Scientific Education

2000-2010
Studies in computer science, Dresden University of Technology, specialization in theoretical computer science, minor in psychology, diploma thesis: „k-best parsing strategies for cyclic grammars and hypergraphs“
 

Professional Experience

2010-present
PhD student, University Hospital Dresden, Department for Child and Adolescent Psychiatry and Psychotherapy
 
2010
Research assistant, Dresden University of Technology, Institute of Theoretical Computer Science
 
2006-2007
Application developer, Qimonda, Dresden
 
2001-2006
Application developer, Infineon Technologies, Dresden
 

Other Scientific Activities, Honors, Awards

2006
Team of the month - April 2006, Qimonda, Dresden
 
2001
Ideas Management Award, Infineon Technologies, Dresden


Selected Publications

Walton E, Geisler D, Lee PH, Hass J, Turner JA, Liu J, Sponheim SR, White T, Wassink TH, Roessner V, Gollub RL, Calhoun VD, Ehrlich S. Prefrontal Inefficiency Is Associated With Polygenic Risk for Schizophrenia. Schizophr Bull. 2014 Nov;40(6):1263-71. Epub 2013 Dec 10.

Walton E, Geisler D, Hass J, Liu J, Turner J, Yendiki A, Smolka MN, Ho BC, Manoach DS, Gollub RL, Roessner V, Calhoun VD, Ehrlich S. The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function. PLoS One 2013 Oct 8:e76815.

Ehrlich S, Geisler D, Yendiki A, Panneck P,Roessner V, Calhoun VD, Magnotta VA, Gollub RL, White T. Associations of WM integrity and cortical thickness in patients with schizophrenia and healthy controls. Schizophr Bull. 2014 May;40(3):665-74. Epub 2013 May 9.

Zwipp J, Hass J, Schober I, Geisler D, Ritschel F, Seidel M, Weiss J, Roessner V, Hellweg R, Ehrlich S. Serum brain-derived neurotrophic factor and cognitive functioning in underweight, weight-recovered and partially weight-recovered females with anorexia nervosa. Prog Neuro-Psychoph. 2014 Oct 3;54C:163-169.

Schneider CE, White T, Hass J, Geisler D, Wallace SR, Roessner V, Holt DJ, Calhoun VD, Gollub RL, Ehrlich S. Smoking status as a potential confounder in the study of brain structure in schizophrenia. Psychiatr Res. 2014 Mar;50:84-91.

Boehm I, Geisler D, King JA, Ritschel F, Seidel M, Deza Araujo Y, Petermann J, Lohmeier H, Weiss J, Walter M, Roessner V, Ehrlich S. Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa. Front Behav Neurosci. 2014 Oct 2;8:346. eCollection 2014.

Ritschel F, King JA, Geisler D, Flohr L, Neidel F, Boehm I, Seidel M, Zwipp J, Ripke S, Smolka MN, Roessner V, Ehrlich S. Temporal delay discounting in acutely ill and weight-recovered patients with anorexia nervosa. Psychol Med. 2015 Apr;45(6):1229-39.

King JA, Geisler D, Ritschel F, Schober I, Seidel M, Roschinski B, Soltwedel L, Zwipp J, Pfuhl G, Marxen M, Roessner V, Ehrlich S. Global cortical thinning in anorexia nervosa normalizes following long-term weight restoration. Biol Psychiatry. 2015 Apr 1;77(7):624-32.

Ehrlich S, Lord AR, Geisler D, Borchardt V, Boehm I, Seidel M, Ritschel F, Schulze A, King JA, Weidner K, Roessner V, Walter M. Reduced functional connectivity in the thalamo-insular subnetwork in patients with acute anorexia nervosa. Human Brain Mapp. 2015 May;36(5):1772-81.

Ehrlich S, Geisler D, Ritschel F, King JA, Seidel M, Boehm I, Breier M, Clas S, Weiss J, Marxen M, Smolka MN, Roessner V, Kroemer NB. Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa. J Psychiatry Neurosci. 2015 Jun 23;40(4):140249.

Geisler D, Borchardt V, Lord A, Boehm I, Ritschel F, Zwipp J, Clas S, King JA, Wolff-Stephan S, Roessner V, Walter M, Ehrlich S. (2015): Abnormal functional global and local brain connectivity in female patients with anorexia nervosa. J Psychiatry Neurosci. 2016 Jan;41(1):6-15.

Lord AR, Ehrlich S, Borchardt V, Geisler D, Seidel M, Huber S, Murr J, Walter M. Brain parcellation choice affects disease-related topology differences increasingly from global to local network levels. Psychiat Res-Neuroim. 2016 Mar;249:12-9.

Boehm I, Geisler D, Tam F, King JA, Ritschel F, Seidel M, Bernardoni F, Murr J, Goschke T, Calhoun VD, Roessner V, Ehrlich S. Partially restored resting-state functional connectivity in women recovered from anorexia nervosa. J Psychiatry Neurosci. 2016 Apr;41(3):150259.

Seidel M, Petermann J, Diestel S, Ritschel F, Boehm I, King JA, Geisler D, Bernardoni F, Roessner V, Goschke T, Ehrlich S. A Naturalistic Examination of Negative Affect and Disease-related Rumination in Anorexia Nervosa. Eur Child Adolesc Psychiatry. 2016 Nov;25(11):1207-1216.

Bernardoni F, King JA, Geisler D, Stein E, Jaite C, Naetsch D, Tam FI, Boehm I, Seidel M, Roessner V, Ehrlich S. Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: A longitudinal study. Neuroimage. 2016 Apr 15;130:214-22.

Pfuhl G, King JA, Geisler D, Roschinski B, Ritschel F, Seidel M, Bernardoni F, Müller DK, White T, Roessner V, Ehrlich S. Preserved white matter microstructure in young patients with anorexia nervosa? Hum Brain Mapp. 2016 Nov;37(11):4069-4083.

King JA, Geisler D, Bernardoni F, Ritschel F, Boehm I, Seidel M, Mennigen E, Ripke S, Smolka MN, Roessner V, Ehrlich S. Altered Neural Efficiency of Decision Making During Temporal Reward Discounting in Anorexia Nervosa. J Am Acad Child Psy. 2016 Nov;55(11):972-979.

Geisler D, Ritschel F, King JA, Bernardoni F, Seidel M, Boehm I, Runge F, Goschke T, Roessner V, Smolka MN, Ehrlich S. Increased anterior cingulate cortex response precedes behavioural adaptation in anorexia nervosa. Sci Rep. 2017 Feb 13;7:42066.



Contact Information

University Hospital Carl Gustav Carus
Division of Psychological and Social Medicine and Developmental Neurosciences
Technische Universität Dresden
Fetscherstraße 74, 01307 Dresden
E-Mail: daniel.geisler(at)uniklinikum-dresden.de